Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person’s own red blood cells (RBCs) cause them to burst (lyse), leading to. Autoimmune hemolytic anemia (AIHA) is an uncommon disorder characterized by hemolysis mediated by autoantibodies directed against. Autoimmune hemolytic anemia is characterized by shortened red blood cell survival and a positive Coombs test. The responsible autoantibodies may be either.

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Healthy individuals often display low-titer cold agglutinins, but in chronic cold agglutinin disease, serum titers may range from 1: Infection is a serious concern in patients on long-term immunosuppressant therapy, especially in very young children less than two years. Associated with lymphoproliferative disorders e. A careful drug history supported by matching serologic findings helps to distinguish drug-induced immune hemolytic anemia.

Clinical history is also important to elucidate any underlying illness or medications that may have led to the disease.

Anemia Hemolitik Autoimun

Less often a patient may note sudden onset of symptoms of severe anemia and jaundice over a few days. Autoimmune hemolytic anemia AIHA is one of the immunological diseases that causes hemolysis.

The more the molecules of IgG, the more the activation of complement, the more is the red cell destruction. Specificity for IgG subclasses and IgG fragments. Coombs-negative AIHA has been reviewed elsewhere [ 26 ]. Presenting complaints of AIHA depends on the severity of anemia itself, ranging from asymptomatic compensated reticulocytosis with mild hyperbilirubinemia to acute fulminant hemolysis leading to jaundice, hematosplenomegaly, tachycardia and angina.


Pathological cold autoantibodies are characterized by large thermal amplitude or a high titer, with thermal amplitude as the better predictor of hemolysis. Thiopental- related immune hemolytic anemia and renal failure. The rate of hemolysis in patients with warm antibody AIHA patients is quite variable and depends only loosely on the strength of the antiglobulin reaction.

Tes Coombs menunjukkan anti-C3 dan ditemukannya cold antibody.

Reticulocytopenia also may be seen in patients with compromised marrow function, parvovirus infection, toxic chemicals, or nutritional deficiency. In another example, autiomun patient presented with acrocyanosis and a high-titer, high-thermal-amplitude, complement-fixing IgM cold agglutinin, without evidence for hemolysis.

Drug-induced antibodies can recognize either intrinsic red cell antigens or red cell-bound drugs. Autoantibodies of U blood group specificity in autoimmune haemolytic anaemia. Weiner W, Vos GH. Since the pathophysiology of CAS typically involves IgM autoantibodies and complement, patients almost exclusively have positive DAT with anti-C3 and polyspecific reagents and a negative result with anti-IgG.

Bull N Y Acad Med. Autoimmune haemolytic anaemia with monoclonal IgM kappa anti-P cold autohaemolysins. Rossi’s Principles of Transfusion Medicine. Skin pallor, icterus and nailbed pallor in a patient with treatment-refractory warm AIHA, hemoglobin 4. A positive Hemolitii reaction shortly following blood transfusion raises the specter of a delayed transfusion reaction, leading to an erroneous impression of an autoimmune process.

New insights into childhood autoimmune hemolytic anemia: Mild leukocytosis and neutrophilia are typical. The DAT remains negative between attacks. The cold hemagglutinin disease. The prevalence is estimated at about 14 per million [ 8 ]. Fatal immune hemolytic anemia due to cefotetan.

The pathology of autoimmune haemolytic anaemia. If the patient has not been recently transfused and does not have a high titer autoantibody, autoadsorption techniques can eliminate the confounding autoantibody and reduce the risk.


Patients afalah more severe disease symptomatic anemia, transfusion dependence may be treated with rituximab. A high-titer, high-thermal amplitude autoanti-B associated with acrocyanosis but no obvious hemolytic anemia.

The resulting alloantibodies show no reactivity towards autologous red cells.

The Clinical Pictures of Autoimmune Hemolytic Anemia

Oxford, Blackwell Science,p Complement fragments, such as C3a, C4a and C5a, activate granular leukocytes e. Cases may also arise with complement alone or with IgAIgM or a combination of these three antibody classes and complement. Incidence of a positive direct coombs test in patients on alpha-methyldopa.

Hypersensitivity and xnemia diseases Diagnosis and classification of autoimmune hemolytic anemia.

A case report with emphasis on pathogenic mechanisms. IgA red cell autoantibodies and autoimmune hemolysis. Lethal autoimmune hemagglutination due to an immunoglobulin A autoagglutinin with Band 3 specificity. Associated with the rheumatic disorders, e. Cases of AIHA generally are classified according to the characteristic temperature reactivity of the red cell autoantibody [ Table 1 ]. Diagnostic Criteria in Autoimmune Disease. Donath-Landsteiner hemolytic anemia in children.

Patients may present with one or both types of autoantibodies; if both are present, the disease is termed “mixed-type” AIHA. Diabetes mellitus type 1 Hashimoto’s thyroiditis Multiple sclerosis Coeliac disease Giant-cell arteritis Postorgasmic illness syndrome Reactive arthritis.

Acute renal failure and death may accompany severe hemolysis [ 141516 ]. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.